Platelet factor VIII-related antigen: studies in vivo after transfusion in patients with von Willebrand disease
Open Access
- 1 April 1978
- journal article
- Published by American Society of Hematology in Blood
- Vol. 51 (4) , 751-761
- https://doi.org/10.1182/blood.v51.4.751.751
Abstract
Four unrelated patients with a severe form of von Willebrand disease showed no detectable factor VIII-related antigen (VIIIR:AG) in either their plasma or their platelets. They received cryoprecipitate infusions, three patients in a single injection each and one every day for 9 days before and after surgery. Platelet VIIIR:Ag was studied at different times during and after transfusion using electroimmunoassay of platelet extracts and electron microscopy of the platelets incubated with anti-VIIIR:Ag antibodies coupled to peroxidase. No VIIIR-Ag was detected in or around the patients' platelets, although this antigen was detected in the circulating blood. These results that there was no VIIIR:Ag uptake from the plasma by the platelets and that platelet VIIIR:Ag came from megakaryocytes.Keywords
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