Pharmacokinetics and neuroendocrinological studies of bromperidol in schizophrenic patients.

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Abstract
Plasma concentrations of bromperidol (BPD) were studied by the single andrepeated administration in schizophrenic patients, and were compared with that ofhaloperidol (HPD). At the same time, plasma levels of prolactin (PRL) were measuredin order to clarify the neuroendocrinological properties of BPD. As the results, therewas no difference between BPD and HPD in pharmacokinetic paramaters observed bythe single administration, but time-concentration curves showed a biphasic pattern, andthe elimination half life of the β phase of BPD was 31.1 hr. and that of HPD was 27.1 hr.When BPD were administered at the daily dose of 9 mg for 28 days, there was nosignificant difference in plasma concentrations between the doses of 3 times a day andonce a day, although HPD concentrations were lower in the administration of once a daythan in 3 times a day. In PRL levels no significant differece was observed between bothdrugs in the single administration, but there was significant correlation between plasma BPD concentration and PRL level in the repeated administration of BPD both in 3times a day and once a day.From these results, it was noted that BPD showed no significant difference in itsplasma concentrasions between the doses of 3 times a day and once a day. Further, significant correlation was found between plasma BPD concentrations and PRL levels.

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