Synthesis of lysergic acid derivatives by triple radical cyclisation
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1543-1544
- https://doi.org/10.1039/c39900001543
Abstract
The lysergic acid ring system, characteristic of the ergot alkaloids, is constructed from 2-bromoaniline derivatives by triple radical cyclisation, initiated with tri-n-butyltin hydride; formation of a 6- rather than a 5-membered D ring is controlled by a terminal phenylthio group.Keywords
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