Imipramine and Desipramine Decrease the GABA-Stimulated Chloride Uptake, and Antigabaergic Agents Enhance Their Action in the Forced Swimming Test in Rats
- 1 January 1990
- journal article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 23 (3) , 147-152
- https://doi.org/10.1159/000119442
Abstract
The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated 36Cl– uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A, B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action.Keywords
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