MECHANISM OF PUPILLARY DILATATION ELICITED BY CORTICAL STIMULATION

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Abstract
Pupillary dilatation elicited by electrical stimulation of area 8 in the cerebral cortex of the monkey is a localized sympathetic response having all the properties of reciprocal innervation. Although the response is usually abolished by section of the cervical sympathetic chain, minimal pupillary dilatation due to inhibition of the oculomotor nucleus may be obtained under special conditions of anesthesia. The active dilator component travels over pathways involving the lateral hypothalamus. This cortico-hypothalamic pathway is not a direct one. The reciprocal inhibitory pathway from area 8 to the oculomotor nucleus has been shown to be a direct projection.

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