Abstract
The case–control study by Lesko et al. in this issue of the Journal 1 is the most recent of several to find that cigarette smoking is less prevalent among postmenopausal women with endometrial carcinoma than among other postmenopausal women. Although the observed association is not strong — an estimated 30 per cent reduction in risk to current smokers — there are several reasons to believe that it indicates a protective effect of smoking in some women. The association has been observed in both population-based and hospital-based studies, and it appears to be strongest in heavy smokers. Furthermore, a negative association between . . .