Enantioselective synthesis of isoquinoline alkaloids

Abstract
The utility of the Pictet–Spengler condensation of (R)-(+)-glyceraldehyde with dopamine hydrochloride in the enantioselective synthesis of isoquinoline alkaloids is demonstrated by the preparation of (S)-(−)-carnegine, (R)-(−)-calycotomine, and (S)-(+)-laudanosine.

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