Decrease in the Number of Rat Brain Dopamine and Muscarinic Receptors after Chronic Alcohol Intake
- 1 April 1988
- journal article
- research article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 62 (4) , 210-212
- https://doi.org/10.1111/j.1600-0773.1988.tb01874.x
Abstract
The effect of 32 weeks' alcohol treatment on the number and affinity of dopamine and muscarinic receptor sites in rat striatum were measured using3H‐spiperone and3H‐quinuclidinylbenzilate (3H‐QNB) as radioligands. The number of dopamine receptor sites was 38 per cent and the number of muscarinic receptor sites 36 per cent lower in the alcohol group than in control rats. The differences in receptor affinities were less marked. In conclusion, a long‐term alcohol intake with rather moderate doses seems to induce a pronounced down‐regulation in dopamine and muscarinic receptor systems in rat striatum.This publication has 16 references indexed in Scilit:
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