Potassium balance in piretanide and digoxin treatment
- 1 March 1982
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 31 (3) , 339-342
- https://doi.org/10.1038/clpt.1982.43
Abstract
Piretanide, a new potent diuretic, was given to 18 healthy male subjects to determine its effect on serum, total body (TBK) and red cell K+ (RCP). TBK and RCP were measured before treatment to establish baseline values, after which all subjects received 6 mg piretanide/day for 14 days. After this period subjects were divided into 2 groups; group 1 received 6 mg/day piretanide for 14 days and group 2 received the same dose of piretanide with 0.5 mg digoxin/day during the remaining 14 days. All treatments were terminated after 28 days, but subjects remained under observation for another 14 days. Serum K+, TBK and RCP were measured weekly during the 42-day period. Piretanide, at 6 mg/day for a period of 6 wk did not induce a fall in serum K+, TBK or RCP. The addition of digoxin for 2 wk after piretanide alone for 2 wk did not decrease serum K+ and TBK, but RCP fell under the influence of piretanide with digoxin.This publication has 0 references indexed in Scilit: