Simple Aziridino Alcohols as Chiral Ligands. Enantioselective Additions of Diethylzinc to N-Diphenylphosphinoylimines
- 1 August 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (08) , 727-728
- https://doi.org/10.1055/s-1996-5529
Abstract
Simple chiral aziridino alcohols 2-5, easily available from L-serine, L-threonine or L-allo-threonine, have been used as ligands to promote the addition of Et2Zn to the diphenylphosphinoylimine 1 (Ar=Ph). Enantioselectivities of up to 94% could be obtained by proper choice of the substituents on the ligand. Up to 90% of the ligand could be recovered during the work-up. The use of ligand 3a as catalyst for the same reaction has also been studied.Keywords
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