Methyprylon

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Abstract
THE purpose of this study was to evaluate the safety and efficacy of methyprylon (3,3-diethyl-2,4-dioxo-5-methylpiperidine),§ a Central-nervous-system depressant, which in laboratory animals had shown a very desirable therapeutic ratio. The program, which was carried out on patients from the population of Long Island Hospital in Boston, consisted of three phases: a pilot experiment to determine whether methyprylon has somnifacient effects in man; a study of chronic toxicity to investigate the safety of the drug if it is given over a prolonged period; and a double blind study of the dose–response relation, including three dosage levels of methyprylon and placebo medication. . . .

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