Theophylline, a new inducer of apoptosis in B‐CLL: role of cyclic nucleotides
- 1 August 1995
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 90 (4) , 957-959
- https://doi.org/10.1111/j.1365-2141.1995.tb05225.x
Abstract
We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 micrograms/ml increased spontaneous apoptosis after 72 h in culture by a mean percentage of 90% (range 79-98%) in six B-CLL cases studied in vitro. This effect was partially reversed with Rp-cAMP, a cAMP antagonist, which implies a potent role for this second messenger. We describe a new property of theophylline, which might be an alternative treatment in B-CLL.Keywords
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