THE TRANSFORMATION OF SERUM ALBUMIN INTO SERUM GLOBULINS
- 22 April 1932
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 75 (1947) , 443
- https://doi.org/10.1126/science.75.1947.443
Abstract
When antiprothrombin (heparin) is added to a protein in solution, its isoelectric point is moved towards the acid side. Serum albumin, which is soluble at its isoelectric point, becomes insoluble when heparin is added. The degree of flocculation depends upon the amount of heparin added. According to the physico-chemical properties of the albumin-heparin compounds, they are identical with the globulins. A parallelism was found between the grade of flocculation of a blood serum at pH 5 and the coagulability of the corresponding plasma. The greater the flocculation, the longer is the coagulation time, i.e., the higher the concentration of heparin. (See entry 3075 in this issue.).This publication has 0 references indexed in Scilit: