Acylimidazolides as Versatile Synthetic Intermediates for the Preparation of Sterically Congested Amides and Ketones: A Practical Synthesis of Proscar®
- 1 September 1990
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 20 (17) , 2683-2690
- https://doi.org/10.1080/00397919008051477
Abstract
Acylimidazolides react with magnesium amides to produce car-boxamides in excellent yields, whereas Fe(III) catalyzed cross coupling between acylimidazolide and Grignard reagents produce ketones in high yields. These methods were utilized to prepare the α-reductase inhibitor Proscar® as well as various 17β-amide and ketone analogs of Δ1-4-aza-5α-androsten-3-one.Keywords
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