Formation of Regulatory Patterns During Signal Propagation in a Mammalian Cellular Network
- 12 August 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5737) , 1078-1083
- https://doi.org/10.1126/science.1108876
Abstract
We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.Keywords
This publication has 22 references indexed in Scilit:
- Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifsBioinformatics, 2004
- Structure of cycles and local ordering in complex networksZeitschrift für Physik B Condensed Matter, 2004
- Dynamics of the p53-Mdm2 feedback loop in individual cellsNature Genetics, 2004
- MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling NetworkScience, 2002
- Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial MemoryNeuron, 2002
- Emergent Properties of Networks of Biological Signaling PathwaysScience, 1999
- Gating of CaMKII by cAMP-Regulated Protein Phosphatase Activity During LTPScience, 1998
- Gating by Cyclic AMP: Expanded Role for an Old Signaling PathwayScience, 1996
- Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding proteinCell, 1994
- Learning-related synaptic plasticity: LTP and LTDCurrent Opinion in Neurobiology, 1991