Synthesis of Gossypol Analogues
- 15 March 1989
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 72 (2) , 353-360
- https://doi.org/10.1002/hlca.19890720221
Abstract
Two gossypol analogues 2a and 2b were synthesized for biological evaluation as male contraceptive agents. The naphthol 8c was prepared by analogy with a known procedure starling from 3‐isopropylcatechol (3). (t‐Bu)2O2‐Mediated phenolic coupling of 8c furnished the binaphthol 9c which, after pyrane ring closure, deprotection. and selective bisformylation with SnCl4/Cl2CHOCH3, gave the target compound 2a. The corresponding tetrahydroxy analogue 2b was prepared in a similar way.This publication has 14 references indexed in Scilit:
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