Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid‐mediated blockade of long‐term potentiation in the rat hippocampal slice
Open Access
- 19 July 1995
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 115 (6) , 869-870
- https://doi.org/10.1111/j.1476-5381.1995.tb15889.x
Abstract
Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (−)−11-OH-Δ8–dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both3HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, co-incubation with3HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.Keywords
This publication has 7 references indexed in Scilit:
- SR141716A, a potent and selective antagonist of the brain cannabinoid receptorPublished by Wiley ,2001
- The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal sliceEuropean Journal of Pharmacology, 1994
- A synaptic model of memory: long-term potentiation in the hippocampusNature, 1993
- Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyJournal of Neuroscience, 1991
- The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitroBrain Research Bulletin, 1987
- Cannabis: Effects on memory and the cholinergic limbic system.Psychological Bulletin, 1983
- Cannabis: Effects on memory and the cholinergic limbic system.Psychological Bulletin, 1983