PERIPHERAL NEUROPATHY AS A COMPLICATION OF CIS-DICHLORODIAMMINEPLATINUM(II) TREATMENT - CASE-REPORT

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 62  (5) , 819-821
Abstract
A 19 yr old woman with osteosarcoma was initially treated by amputation of the right leg and adjuvant adriamycin. She developed pulmonary metastases 18 mo. following diagnosis. She was then given cis-dichlorodiammineplatinum(II) (DDP) at a dose of 100 mg/m2 i.v. approximately every 4 wk as the sole drug. Following the 5th dose of DDP, she complained of numbness and tingling in her hands and leg. A distal sensory loss extending to both elbows and remaining knee was found on examination. Nerve conduction tests were compatible with peripheral neuropathy of the glove-and-stocking type. DDP was withheld and her sensory loss improved over the next 2 mo., but became worse after another course of DDP was administered. The temporal relationship between the findings and administration of DDP implicates this drug as the causative agent in the peripheral neuropathy.

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