Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron
- 15 February 1984
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 218 (1) , 273-275
- https://doi.org/10.1042/bj2180273
Abstract
Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells produced by H2O2. These results, taken together with our previous findings, indicate that the DNA damage is produced by hydroxyl radicals formed when H2O2 reacts with chromatin-bound Fe2+ and that this damage is responsible for the killing effect.Keywords
This publication has 13 references indexed in Scilit:
- Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.Published by Elsevier ,2021
- Free radical pathology: Inactivation of human α-1-proteinase inhibitor by products from the reaction of nitrogen dioxide with hydrogen peroxide and the etiology of emphysemaBiochemical and Biophysical Research Communications, 1982
- Mutagenicity of oxygen free radicals.Proceedings of the National Academy of Sciences, 1982
- Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.Journal of Biological Chemistry, 1981
- The damaging action of hydrogen peroxide on DNA of human fibroblasts is mediated by a non-dialyzable compoundBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980
- Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.Proceedings of the National Academy of Sciences, 1980
- Neuronal cell damage in the brain: possible involvement of oxidative mechanisms.1980
- Gaps in DNA synthesized by ultraviolet light-irradiated WI38 human cellsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
- Superoxide DismutasesAnnual Review of Biochemistry, 1975
- Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide DismutaseScience, 1974