Effect of Diazoalkane-yielding Compounds on Strains of Escherichia coli Resistant to 1-Methyl-3-nitro-1-nitrosoguanidine.

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Abstract
A series of analogues of l-methyl-3-nitro-1-nitrosoguanidines (NG), differing in the alkyl substituent, was tested against 2 mutants of Escherichia coli strain S, selected for successively increasing resistance to NG. In general, increasing resistance to NG was observed to be accompanied by increasing resistance to all the nitrosoguanidines. When N-methyl-N-nitrosourea and N-methyl-N-nitroso-p-toluenesulfonamide were tested against NG-resistant strains of E. coli, it was found that the first step resistant mutant was cross-resistant. However, the second step mutant, derived from the first, was more sensitive to both of these compounds than was the first step mutant. A first step mutant of E. coli strain S, selected for resistance to N-methyl-N-nitrosourea, was resistant to NG. S-methyl-N-nitro-pseudothiourea did not inhibit E. coli strain S.