Immunization with the malaria heat shock like protein hsp70-1 enhances transmission to the mosquito

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Abstract
Mosquitoes fed on mice infected with Plasmodium yoelii after an immunization with the 172 recombinant form of the heat shock protein hsp70-1 developed significantly more oocysts than mosquitoes fed on controls. This effect was due to a marked increase in the relative numbers of gametocytes during the early stages of infection. A comparison of blood-induced and sporozoite-initiated infection showed that these gametocytes were derived from merozoites released from the liver. The stimulus for increased gametocyte production is unknown but is likely to be linked with antibody-dependent cellular cytotoxicity and associated cytokine responses.

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