The alternatively spliced exon of the platelet-derived growth factor A chain encodes a nuclear targeting signal.
Open Access
- 1 May 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (5) , 2251-2253
- https://doi.org/10.1128/mcb.9.5.2251
Abstract
We have previously shown that the SIS/platelet-derived growth factor B chain contains a nuclear targeting signal near its C terminus. Here we show that the platelet-derived growth factor A chain also contains a nuclear targeting signal encoded by an exon which is subject to alternative splicing. This sequence is capable of targeting a nonsecreted form of the A chain to the nucleus and can also target the cytoplasmic proteins dihydrofolate reductase, chloramphenicol acetyltransferase, and pyruvate kinase to the nucleus.This publication has 21 references indexed in Scilit:
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