Improved Synthesis of O‐Phosphohomoserine
- 1 January 1975
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 58 (2) , 518-521
- https://doi.org/10.1002/hlca.19750580221
Abstract
O‐Phosphohomoserine (PHS) was prepared in an overall yield of 49% by treatment of N‐benzyloxycarbonyl‐homoserine p‐nitrobenzyl ester with diphenylphosphoryl chloride in pyridine, followed by catalytic hydrogenolysis. Both L‐ and D, L‐phosphohomoserine were found to be 100% hydrolyzed by alcaline phosphatase from E. coli.Keywords
This publication has 17 references indexed in Scilit:
- Synthesis of homoserine phosphate and a blocked derivative suitable for peptide synthesisThe Journal of Organic Chemistry, 1973
- Zum Vorkommen von Thiothreonin im PflanzenmaterialCellular and Molecular Life Sciences, 1973
- IUPAC - IUB Commission on Bio-Chemical Nomenclature Symbols for Amino-Acid Derivatives and Peptides. Recommendations (1971).Biochemistry, 1972
- Synthesis and application in peptide chemistry of amino acids possessing an optically active selenohomocysteine skeletonThe Journal of Organic Chemistry, 1970
- Peptide synthesis via oxidation of N-acyl-.alpha.-amino acid phenylhydrazides. II. Benzyloxycarbonyl peptide phenylhydrazidesThe Journal of Organic Chemistry, 1968
- The Isolation of Phosphorylhomoserine from Trichloroacetic Acid Extracts of Lactobacillus casei.Acta Chemica Scandinavica, 1962
- Use of Chlorine in the Detection of Compounds on Paper ChromatogramsNature, 1960
- The Oxidative Cleavage of Phenylhydrazide Groups from Carboallyloxy-α-amino Acid Phenylhydrazides and Carboallyloxydipeptide Phenylhydrazides1,2Journal of the American Chemical Society, 1957
- O-Phosphorylserine.Acta Chemica Scandinavica, 1957
- Über eine Färbemethode zum Anfärben von Aminosäuren, Peptiden und Proteinen auf Papierchromatogrammen und PapierelektropherogrammenEuropean Journal of Inorganic Chemistry, 1954