Special regulatory T‐cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression
- 11 December 2007
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 123 (1) , 17-19
- https://doi.org/10.1111/j.1365-2567.2007.02774.x
Abstract
FOXP3 is an acetylated and phosphorylated protein active in human regulatory T cells and forms oligomers which then associate with an even larger molecular complex. FOXP3 actively regulates transcription by recruiting enzymatic co-repressors and/or co-activators. FOXP3 complex ensembles are dynamically regulated by physiological stimuli such as T-cell receptor, IL-2 and proinflammation cytokine signals. Understanding the post-translational modifications of FOXP3 regulated by diverse signals and the biochemistry and structural chemistry of enzymatic proteins in the FOXP3 complex is critical for therapeutically modulating regulatory T cell function.Keywords
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