Observations on the Use of Antithyroid Drugs

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Abstract
Fifty-seven % of 167 patients treated for hyperthyroidism with antithyroid drugs achieved euthyroidism that has been maintained for from 4 to 19 years. A satisfactory remission occurred more often in those with small goiters, mild toxicity and symptoms of relatively short duration. Unfavorable reactions did not exceed 2%. In post-operative or recurrent hyperthyroidism the response, while favorable, required an average of 20 months''treatment, longer than when radioactive iodine is used. When pregnancy and hyperthyroidism coexisted the pregnancy continued to term with delivery of a normal infant when antithyroid medication was stopped at the 28th week and replaced by iodine or desiccated thyroid. The response to antithyroid therapy in the diabetic with hyperthyroidism was variable. Improved control of the diabetes was noted when the diabetes was either mild or stable.

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