INVIVO STUDIES ON THE UTILIZATION OF MONO-L-ASPARTYL CHLORIN (NPE6) FOR PHOTODYNAMIC THERAPY

  • 1 September 1987
    • journal article
    • research article
    • Vol. 47  (17) , 4681-4685
Abstract
The in vivo photosensitizing efficacy of mono-L-aspartyl chlorin has been studied by determining the percentage of BALB/c mice cured at varying doses of drug. Using an EMT-6 tumor model, animals received i.p. injections of mono-L-aspartyl chlorin (0.5-100 mg/kg) and then were subsequently exposed to light at 664 nm. Tumor biopsies were taken from selected animals sacrificed at 24 h after treatment and routine histopathological sections made. The other animals remained in the dark for a period of 6 weeks to determine the cure rate. Our results show that mono-L-aspartyl chlorin is an effective tumor localizer that brings about the selective degradation of tumor tissue following light exposure.