Immunoglobulin Synthesis on Free and Bound Polyribosomes of Rabbit Lymph Node Cells
Open Access
- 1 January 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 106 (1) , 69-73
- https://doi.org/10.4049/jimmunol.106.1.69
Abstract
Lymph node cells from immunized rabbits were pulse-labeled in vitro with 3Hleucine and fractionated on sucrose gradients to separate free and membrane-bound polyribosomes. Nascent polypeptides released from polyribosomes were precipitated with antiserum specific for rabbit immunoglobulin. The results indicate that immunoglobulin is synthesized preferentially by bound polyribosomes.Keywords
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