ANTITUMOR ACTIVITY OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL IN A VARIETY OF EXPERIMENTAL-TUMORS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (5) , 725-731
Abstract
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil against various tumors was examined. Therapeutic ratio in the L-1210 mouse leukemia system was 4.5 by oral administration, while those of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil were 1.9 and 1.0, respectively. This hexylcarbamoyl derivative was active against solid tumors such as Nakahara-Fukuoka sarcoma and adenocarcinoma 755 by oral administration.

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