The Metabolism of [carboxyl-14C]Anthranilic Acid

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Abstract
A new pathway of NAD+ synthesis from anthranilic acid was found in the livers of rats. Starting from [rcarboxyl-14C]anthranilic acid, radioactive NAD+ and NADP+ were produced as judged by Dowex-1 ×8-formate column chromatography followed by radiochromatography. Several intermediate compounds, such as quinolinic acid, nicotinic acid mononucleotide, and nicotinic acid adenine dinucleotide were also identified with the aid of various chro-matographic techniques. In the experiments with liver microsomal hydroxylation systems, anthranilic acid was converted into not only 5-hydroxyanthranilic acid but also 3-hydroxy-anthranilic acid.