A Biological Model Describing Tissue Distribution and Whole-body Retention of Barium and Lanthanum in Beagle Dogs After Inhalation and Gavage
- 1 November 1972
- journal article
- research article
- Published by Wolters Kluwer Health in Health Physics
- Vol. 23 (5) , 621-633
- https://doi.org/10.1097/00004032-197211000-00004
Abstract
Whole-body retention and tissue distribution of inhaled 140Ba - 40La and whole–body retention of ingested 133Ba were studied in Beagle dogs after administration in soluble chloride forms. The resulting data were used to formulate a biological retention model which was executed with both analog and digital computer methods. This model was then used to estimate radiation protection guidelines for human exposure to soluble and relatively insoluble aerosols of 140Ba and 133Ba. The biological tissues receiving the most significant radiation doses were predicted to be the skeleton after inhalation of 140BaCl2 and 133BaCl2 and the lung after inhalation of 140BaSO4. The influence of species differences, age, dietary state at the time of inhalation exposure and aerosol particle size upon the calculation of (MPC)a guidelines was also discussed.Keywords
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