Lack of Tolerance to the Bradycardic Effect of Δ9-trans-Tetrahydrocannabinol in Rats
- 1 January 1974
- journal article
- Published by S. Karger AG in Pharmacology
- Vol. 12 (4-5) , 290-295
- https://doi.org/10.1159/000136550
Abstract
Acute and chronic effects of Δ9-tetrahydrocannabinol (THC) on the heart rate were studied in unanesthetized rats. THC produced a negative chronotropic effect. Contrary to the many other effects of THC, tolerance did not develop to the bradycardic effect after 16 days of administration. The possible mechanisms of the chronotropic effect of THC are discussed.Keywords
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