Finite amplitude effects on the thresholds for lesion production in tissues by unfocused ultrasound

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Abstract
The phenomenon of thermal lesion production in tissues by unfocused ultrasound has been modeled under the assumptions that damage to the tissues is the result of a chemical rate process and that the time-temperature exposure of the tissue results from a competition between the rate of heat generation by absorption of ultrasonic energy and thermal diffusion. The model was tested by observing thresholds for color change in samples of excised bovine liver at 6 cm from a 2.25 MHz, 1.27 cm diameter piston source and 11.5 cm from a 4.4 MHz, 1.27 cm source. The observations disagreed sharply with predictions of the linear model. After recognition of the fact that finite amplitude phenomena modify the effective absorption coefficients of the tissues, the model gives excellent predictions of observed thresholds simply by using intensity dependent values of the absorption coefficients in the numerical calculations. Thermoelectric and radiation force methods were used to demonstrate the nonlinear absorption phenomenon in excised liver. In contrast to the case of focused ultrasound, the thresholds for lesion formation by unfocused sources occur at lower intensities, are strongly dependent upon frequency and because acoustic saturation in the coupling medium imposes lower limits on tissue intensities for unfocused than for focused ultrasound, unfocused lesions are limited to relatively long exposure times.
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