The effect of ipriflavone (TC-80) on bone resorption in tissue culture
Open Access
- 1 April 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 1 (2) , 207-211
- https://doi.org/10.1002/jbmr.5650010207
Abstract
The fetal long bone culture system developed by Raisz for the assessment of bone resorption was modified to improve the sensitivity, by using radii and ulnae separately, based on the observation of the consistently higher release of 45Ca from the radii than ulnae. Effects of ipriflavone (TC-80), an isoflavonoid derivative currently under clinical trial for its effect on osteoporosis, on bone resorption were examined in this new system. Ipriflavone and its metabolites (5 out of 6) at 10 μg/ml or more inhibited basal 45Ca release from bones. The inhibitory effects were still demonstrated in the presence of submaximal concentration of parathyroid hormone (12.5 ng/ml). The effect of ipriflavone on bone resorption was apparently not due to its toxicity on bone cells, since the inhibition was reversible.Keywords
This publication has 4 references indexed in Scilit:
- Prostaglandin E2 and 2-chloroadenosine act in concert to stimulate bone resorption in cultured murine calvarial bonesBiochemical Pharmacology, 1985
- Metabolism of ipriflavone (TC-80) in rats.RADIOISOTOPES, 1985
- Regulation of Bone FormationNew England Journal of Medicine, 1983
- Bone Resorption in Tissue Culture. Factors Influencing the Response to Parathyroid Hormone *Journal of Clinical Investigation, 1965