Influence of Levamisole on the Immune Response of Old People

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Abstract
Fifteen healthy people, over 70 yr old, were treated for 1 mo. with levamisole at the dose of 150 mg a day, twice a week. They were compared to 15 controls matched for age and sex. At the start of the study, each subject was injected with 0.2 ml of a diphtheria-tetanus vaccine. Levamisole had no effect on the following immune parameters known to be altered in old age: serum Ig[immunoglobulin]G concentration, specific IgE and IgG antibody response to diphtheria toxin, and, lymphocyte response to phytohemagglutinin (PHA). There was a slight and transitory effect of levamisole on the isohemagglutinin titer. In vitro, levamisole was weakly mitogenic for the peripheral blood lymphocytes from old and young control subjects but there was no influence on the response to PHA.

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