Expression of HLA-DR antigens at the surface of mouse L cells co-transfected with cloned human genes
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 303 (5919) , 670-674
- https://doi.org/10.1038/303670a0
Abstract
The H-2 I region in the mouse and the HLA-D region in humans contain a set of polymorphic genes which encode Ia antigens and control the immune response. Cloned genes for the different polypeptide chains of one of the human Ia antigens, HLA-DR, have been used for the co-transformation of mouse L cells. Expression of HLA-DR antigens at the surface of transfected mouse cells has been documented with monoclonal antibodies.Keywords
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