Mechanism of Prophylaxis by Silver Compounds against Infection of Burns
- 23 May 1970
- Vol. 2 (5707) , 444-446
- https://doi.org/10.1136/bmj.2.5707.444
Abstract
To clarify tthe mechanism by which local application of silver compounds protects burns against infection, an ion-specific electrode was used to measùre the concentration of silver ions in solutions. By this method it was shown that in burn dressings silver ions were reduced to a very low level by precipitation as silver chloride. The antibacterial effect was found to depend on the availability of silver ions from solution in contact with precipitate. Between 10-5 and 10-6 molar silver nitrate solution in water was rapidly bactericidal. The minimal amount of silver nitrate causing inhibition of respiration of skin in tissue culture was about 25 times the minimal concentration of silver nitrate that inhibited growth of Pseudomonas aeruginosa.Keywords
This publication has 6 references indexed in Scilit:
- Control of pseudomonas infection in burns by silver sulfadiazine.1969
- LOCAL CHEMOPROPHYLAXIS FOR BURNS WITH GENTAMICIN AND OTHER AGENTSThe Lancet, 1968
- Use of Topical Silver Nitrate, Mafenide, and Gentamicin in the Burn PatientPublished by American Medical Association (AMA) ,1967
- Antiseptic and aseptic prophylaxis for burns: use of silver nitrate and of isolators.BMJ, 1966
- Treatment of Large Human Burns With 0.5% Silver Nitrate SolutionArchives of Surgery, 1965
- THE COMPARATIVE TOXICITY OF ANTIBIOTICS TO SKINBritish Journal of Pharmacology and Chemotherapy, 1959