The New Penicillins

Publisher Website
Google Scholar
Abstract
Broad-Spectrum PenicillinsAmpicillinAmpicillin (alpha-aminobenzyl penicillin), the first of the semisynthetic penicillins to provide increased activity against gram-negative bacteria, was prepared by Doyle et al.156 It is of interest not only for its own activity but also because it provided reason for optimism about the prospects of preparing other new penicillin-like compounds in the future with even wider spectrums and greater activity for organisms against which the penicillins now available are essentially ineffective. Stewart157 recently summarized some of the laboratory and clinical reports.The in vitro susceptibility of gram-positive and gram-negative organisms to ampicillin has been extensively studied in several . . .