ESTIMATION OF THE PHOSPHOLIPID PHOSPHORUS TURNOVER TIME IN MAN: STUDIES IN NORMAL INDIVIDUALS, IN PATIENTS WITH THE NEPHROTIC SYNDROME AND IN OTHER TYPES OF HYPERLIPEMIA 1

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Abstract
In 6 normal in-dividuals and in 8 patients with hyperlipemia, the specific activity of plasma lipid P and urine phosphate was measured following intravenous injection of p32 labeled inorganic P. The specific activity of plasma inorganic and urine total phosphate was essentially the same 24 hours after injection of labile P and thereafter. Turnover time of phospholipid P contained in the plasma plus liver was calculated from these data and in 6 normal individuals this was estimated to be 60-95 hours. In patients with nephrosis and in a patient with untreated hypothyroidism the specific activity of plasma lipid P, in relation to that of urine phosphate, increased more slowly than in normal individuals, while in a patient with biliary cirrhosis it increased at a nearly normal rate. Intermediate values were obtained in one patient with familial hypercholesterolemia. The most likely interpretatior of the findings in the patients with nephrosis seems to be a delay in the attainment of isotopic equilibrium between plasma and liver phospholipids.