CORAMINE (NIKETHAMIDE) IN BARBITURATE POISONING: COMPARISON WITH PICROTOXIN; PRELIMINARY REPORT

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Abstract
A critical survey, comparing the effects of 2 analeptics coramine (nikethamide) and picrotoxin, in the treatment of barbiturate poisoning was made on 99 cases at the Queens General Hospital, Jamaica, N. Y. during the years 1942-1946. The depth of narcosis was detd. essentially by the reactions of reflexes with the most severe grade (grade 4) showing complete areflexia, including the corneal reflex. Treatment consisted of gastric lavage, clearing the air passages, penicillin therapy, good nursing care and doses of the above drugs intraven. Slightly better results were obtained using coramine. Picrotoxin frequently caused convulsions. The most common cause of death was aspiration pneumonia, the mortality rate being 9%.

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