Hypertension in a patient with hypercalcemia: captopril and verapamil
- 1 January 1982
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 142 (1) , 143-145
- https://doi.org/10.1001/archinte.142.1.143
Abstract
A 38-yr-old woman with hypercalcemia, severe hypertension and high renin levels were treated with the angiotensin-converting enzyme inhibitor captopril. This therapy, together with spironolactone, normalized blood pressure (BP), but even with 3 daily administrations of the converting enzyme inhibtor, intermittent rebound hypertension could not be avoided. The administration of only verapamil, an antagonist of Ca transport, did not induce BP control, but when verapamil therapy was combined with administration of captopril and spironolactone, BP could be normalized with only twice-daily administration of the converting enzyme inhibitor. High plasma Ca levels seem to sensitize the arterioles to the intermittent increase of angiotensin II levels that accompanies captopril therapy.This publication has 1 reference indexed in Scilit:
- Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive PatientsAnnals of Internal Medicine, 1979