Bicyclic pyrimidine derivatives with a bridgehead nitrogen atom. Part I. Synthesis of s-triazolo[4,3-a]pyrimidines
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 498-502
- https://doi.org/10.1039/j39670000498
Abstract
The reaction of 2-hydrazinopyrimidines with ethyl imidate hydrochlorides has been explored as a new route to 3-substituted s-triazolo[4,3-a]pyrimidines. The synthesis of certain s-triazolo[4,3-a]pyrimid-7-ones by lead tetra-acetate oxidation of 1-alkyl-2-benzylidenehydrazinopyrimid-6-ones is described. 6-Ethoxycarbonyl-s-triazolo[4,3-a]pyrimid-7-ones readily isomerise to s-triazolo[1,5-a]pyrimid-5-ones.Keywords
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