Adaptive mutation: A general phenomenon or special case?
- 1 January 1997
- Vol. 19 (1) , 9-11
- https://doi.org/10.1002/bies.950190104
Abstract
A recent article by Galitski and Roth(1) characterizes adaptive reversion of chromosomal lac− mutations in Salmonella typhimurium LT2. Using a classical genetic approach they show that adaptive reversion, as characterized by the appearance of late revertant colonies, is an exception rather than a general phenomenon for reversion of nonsense, missense, frameshift and insertion mutations. For certain mutations, however, the number of late revertants exceeds the predicted number. These excess revertants suggest that adaptive mutability is applicable to chromosomal genes as well as to genetic changes involving F plasmids and lysogenic phages.Keywords
This publication has 32 references indexed in Scilit:
- Adaptive Mutation in Escherichia coli : a Role for ConjugationScience, 1995
- Adaptive Mutation: Who's Really in the Garden?Science, 1995
- Evidence that F Plasmid Transfer Replication Underlies Apparent Adaptive MutationScience, 1995
- In pursuit of a molecular mechanism for adaptive mutationGenome, 1994
- ADAPTIVE MUTATION: The Uses of AdversityAnnual Review of Microbiology, 1993
- The Directed Mutation Controversy and Neo-DarwinismScience, 1993
- Experimental evidence for an alternative to directed mutation in thebgl operonNature, 1992
- If it smells like a unicorn · · ·Nature, 1990
- A unicorn in the gardenNature, 1988
- The origin of mutantsNature, 1988