A Preparative Synthesis of D,L-Gabaculine
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 9 (8) , 741-750
- https://doi.org/10.1080/00397917908064188
Abstract
The γ-aminobutyric acid-α-ketoglutaric acid transaminase inhibitor, gabaculine (1) was first isolated as an optically active amorphous powder from a culture filtrate of streptomyces toyacaenis subspecies 1039 by Mishima and co-workers in 19761. The structure (1) was assigned on the basis of physical and chemical data and has been confirmed by two total syntheses of the racemic compound1,2.Keywords
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