Linguistic analysis of protein folding
- 29 July 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 390 (3) , 249-252
- https://doi.org/10.1016/0014-5793(96)00727-2
Abstract
Folding of nascent chains resembles the decoding of spoken language in that information is emitted as a unidirectional, one‐dimensional string of elements, with higher structures and long‐distance interactions emerging with time. Applying a ‘pseudolinguistic’ analysis of structure to a set of all 36 possible six‐stranded antiparallel β‐sandwich topologies reveals new order principles and reduces the complexity of this family significantly. The simple connectivity diagrams (‘linguistic trees’) proposed here allow predictions of the speed and cooperativity of β‐sheet folding and help understanding the cotranslational folding from the N‐terminus.Keywords
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