GRANULOMATOUS ULCER OF THE NOSE AND FACE: OF UNKNOWN CAUSE, USUALLY PROGRESSIVE, GANGRENOUS AND FATAL

1 November 1941

journal article
research article
Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery

Vol. 34 (5) , 865-879
https://doi.org/10.1001/archotol.1941.00660040935001

Abstract

This presentation will consist of a short review of the literature on the subject described by the title and a report of 4 cases in which treatment was given by personal acquaintances or by me. A fifth case is mentioned, which closely resembles those which terminated fatally. It is hoped that this study will stimulate interest in the subject and possibly lead to further research in this country concerning the cause of the disease. REVIEW OF THE LITERATURE Fatal granulomatous ulcerations of the nose and face have been described under various titles. In 1896 McBride¹described a "case of rapid destruction of the nose and face." The following year Jones²described a case of "esthiomenic menstrual ulcer of the nose." In 1906 Fordyce³presented "a case of undetermined tropical ulcer involving the nose, pharynx and larynx, with histological findings." In 1914 Nabarro⁴discussed "an obscure case of ulceration of the

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