STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA XVIII: THE SYNTHETIC OPIATES
Open Access
- 1 November 1969
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 41 (11) , 987-993
- https://doi.org/10.1093/bja/41.11.987
Abstract
The sedative and toxic properties of eleven synthetic analgesics (levorphanol, phenazocine, pentazocine, pethidine, anileridine, phenoperidine, fentanyl, methadone, dipipanone, dextromoramide and phenadoxone) have been determined by giving them, in a double-blind trial, as pre-anaesthetic medication to a standard female population. Levorphanol produced the best sedation while phenoperidine, dipipanone and dextromoramide were also effective in calming the patient. Fentanyl was least efficient in this respect. Pethidine and fentanyl were the most toxic drugs while pentazocine and dipipanone showed least toxicity.Keywords
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