Tumor-Associated Transplantation Antigens of Myelomas Induced in BALB/c Mice2

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Abstract
BALB/c mice were immunized with irradiated murine myeloma cells, then challenged with viable homologous or heterologous tumor cells. The percentage of successful tumor grafts was significantly lower in immunized animals than in controls. This indicated that murine myelomas have tumor-associated transplantation antigen(s) (TATA). The TATA was relatively weak; immunity was established only after numerous inoculations. The transplantation immunity was overcome when the viable tumor cell challenge assay was carried out with high cell concentrations. Immunity to a given tumor line cross-reacted with 4 other lines independent of the types of immunoglobulin produced or the original inducing agents.

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