Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide
Open Access
- 1 August 1996
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 118 (7) , 1567-1569
- https://doi.org/10.1111/j.1476-5381.1996.tb15576.x
Abstract
The novel heptadecapeptide opioid, nociceptin, produced a concentration‐dependent (EC50 28 nM) suppression of the inotropic response of the guinea‐pig isolated renal pelvis to electrical stimulation, a response mediated by release of tachykinins from sensory nerves. Nociceptin did not affect the response to neurokinin A, indicating a prejunctional site of action on tachykininergic nerves. The effect of nociceptin was unchanged in the presence of the μ, δ and ***k opioid receptor antagonists, naloxone, naltrindole and nor‐binaltorphimine.Keywords
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