DETECTION OF GENETIC-HETEROGENEITY BETWEEN FAMILIES OF INSULIN-DEPENDENT DIABETES-MELLITUS PATIENTS USING LINKAGE ANALYSIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 37  (1) , 102-113
Abstract
Much debate has taken place over the mode(s) of inheritance of insulin-dependent diabetes mellitus (IDDM) and the possibility of etiological heterogeneity. The disease status (IDDM) and genetic marker (HLA-A/B haplotype) data were analyzed from 61 multiple-case IDDM famillies ascertained through 2 registries in the Pittsburgh, Pennsylvia, USA, area. Linkage analysis results were similar for 5 previously published simple models of transmission. No heterogeneity could be detected on the basis of the total sample or when the sample was categorized according to the proband''s HLA-B or HLA-DR type. Categorizing the families by generation(s) of the affected individuals revealed differences in the linkage analysis results. Families with affected siblings only (N = 38) showed strong evidence for close linkage for all models. Families with a parent and sibling affected (N = 6) showed evidence against close linkage between HLA-B and IDDM for some models.