Ror γ ( Rorc ) Is a Common Integration Site in Type B Leukemogenic Virus-Induced T-Cell Lymphomas
- 1 May 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (9) , 4943-6
- https://doi.org/10.1128/jvi.78.9.4943-4946.2004
Abstract
The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Ror γ locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Ror γ isoforms in >77% of the tumors tested may complement apoptotic effects of c- myc overexpression.Keywords
This publication has 36 references indexed in Scilit:
- The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patchesImmunological Reviews, 2003
- All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβNature Structural & Molecular Biology, 2003
- Proviral activation of the tumor suppressor E2a contributes to T cell lymphomagenesis in EμMyc transgenic miceOncogene, 2002
- Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient miceNature Genetics, 2002
- New genes involved in cancer identified by retroviral taggingNature Genetics, 2002
- Type B Leukemogenic Virus Has a T-Cell-Specific Enhancer That Binds AML-1Journal of Virology, 2001
- MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathwaysOncogene, 2000
- Genomic Structure and Chromosomal Mapping of the Nuclear Orphan Receptor RORγ (RORC) GeneGenomics, 1997
- Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancerSeminars in Cancer Biology, 1995
- Breakpoints of burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYCGenes, Chromosomes and Cancer, 1994